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KMID : 0357220010130010061
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Journal of Korean Society Physical Therapy
2001 Volume.13 No. 1 p.61 ~ p.72
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Cholinergic Contraction to the Perivascular Nerve Stimulation on the Isolated Coronary Artery of Pig
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이한기/Lee, Han Ki
구봉오/문상은/심철수/Goo, Bong-Oh/Moon, Sang-Eun/Shim, Chul-Soo
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Abstract
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The purpose of this study is to identify clearly the physiologic significance of autonomic nervous system. This study is to find the loose of endogenous neurotransmitter while using the neural response of the neural excitatory action, which is distributed to the perivascular smooth muscle through the electrical stimulation of the smooth muscle of coronary artery of pig.
The effects of perivascular nerve stimulation were investigated on isolated coronary artery of pig.
1. The magnitude of contractile response to perivascular nerve stimulation increased with increasing frequency (2 - 80 Hz) of stimulation.
2. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, lmin) were increased greatly by pretreatment of the cholinestrase inhibitor physostigmine.
3. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1 min) was antagonised markedly by the muscarinic antagonist atropine.
4. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, I mill´) was blocked by the neural blocker. tetrodotoxin.
5. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, lmin) were not affected significantly by the -adrenergic antagonist phentolamine or - adrenergic-antagonist propranolol.
6. The contractile response by the acetylcholine was increased by the pretreatment of cholinestrase inhibitor physostigmine.
The finding suggest that it is powerful excitatory action linked to muscarinic receptor by cholinergic nerve in coronary artery of pig.
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